tesamorelin

Term ID

CHEBI:63626

Synonyms

GHRH(1-44)
N-[(3E)-1-oxo-3-hexenyl]Somatoliberin (human pancreatic islet)
N-[(3E)-hex-3-enoyl]-L-tyrosyl-L-alanyl-L-alpha-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucylglycyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-g
N-[(3E)-hex-3-enoyl]-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg--Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2
tesamorelin
tesamorelina
tesamoreline
tesamorelinum
TH 9507
TH-9507
TH9507

Definition

A polypeptide that is a synthetic analogue of human GRF (Growth Releasing Factor) comprised of the 44 amino-acid sequence of human GRF with a hex-3-enoyl moiety attached to the tyrosine residue at the N-terminal part of the molecule. It is used to stimulate human GRF receptors.

References

cas:218949-48-5
chemspider:34982925
drugbank:DB08869
kegg.drug:D06655
pubmed:14596257
pubmed:18069152
pubmed:19243281
pubmed:20101189
pubmed:20554713
pubmed:20943777
pubmed:21115997
pubmed:21283099
pubmed:21516030
pubmed:21591600
pubmed:21668043
pubmed:21687371
pubmed:21695284
pubmed:22050344
pubmed:22096409
pubmed:22298602
pubmed:22495074
pubmed:22926095
pubmed:24178787
pubmed:25038357
pubmed:25358450
pubmed:25895899
pubmed:26457580
pubmed:27121785
pubmed:28617838
pubmed:28832410
pubmed:30764032
pubmed:31237318
pubmed:31611037
pubmed:31611038
pubmed:32701508
wikipedia.en:Tesamorelin

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from tesamorelin

Phenotype where environments contain tesamorelin

Phenotype modified by environments containing tesamorelin

Phenotype affecting tesamorelin

Human Disease Model