Search Ontology:
ChEBI

pergolide

Term ID
CHEBI:63617
Synonyms
  • (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline
  • pergolida
  • pergolide
  • pergolidum
Definition
A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_role
inverse is_conjugate_acid_of
is_conjugate_base_of
Phenotype
Phenotype resulting from pergolide
Phenotype where environments contain pergolide
Phenotype modified by environments containing pergolide
Human Disease / Model Data
Citations
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