nelarabine

Term ID

CHEBI:63612

Synonyms

2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine
9-(beta-D-arabinofuranosyl)-6-methoxy-9H-purin-2-amine
Arranon
Nelzarabine

(all 4)

Definition

A purine nucleoside in which O-methylguanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. Inhibits DNA synthesis and causes cell death; a prodrug of 9-beta-D-arabinofuranosylguanine (ara-G).

References

(all 21)

Ontology

ChEBI ( EBI )

Relationships

is a type of: beta-D-arabinoside monosaccharide derivative purine nucleoside

beta-D-arabinoside monosaccharide derivative purine nucleoside Show first 5 Terms
has_functional_parent: 9-beta-D-arabinofuranosylguanine guanine

9-beta-D-arabinofuranosylguanine guanine Show first 5 Terms
has_role: antineoplastic agent DNA synthesis inhibitor prodrug

antineoplastic agent DNA synthesis inhibitor prodrug Show first 5 Terms

Phenotype

Phenotype resulting from nelarabine

Phenotype where environments contain nelarabine

Phenotype modified by environments containing nelarabine

Phenotype affecting nelarabine

Human Disease Model