maraviroc

Term ID

CHEBI:63608

Synonyms

4,4-difluoro-N-{(1S)-3-[(3-exo)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide
maraviroc
maravirocum

Definition

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4,4-difluorocyclohexanecarboxylic acid and the primary amino group of (1S)-3-[(3-exo)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropylamine. An antiretroviral drug, it prevents the interaction of HIV-1 gp120 and chemokine receptor 5 (CCR5) necessary for CCR5-tropic HIV-1 to enter cells.

References

cas:376348-65-1
drugbank:DB04835
kegg.drug:D06670
pubmed:21134404
pubmed:21383098
pubmed:21393136
pubmed:21505306
pubmed:21595497
pubmed:21692669
pubmed:21987241
pubmed:22017448
pubmed:22034870
pubmed:22064539
pubmed:22090117
pubmed:22118500
pubmed:22174038
pubmed:22236118
pubmed:22247337
pubmed:24419064
pubmed:24651825
pubmed:24652492
pubmed:25017682
reaxys:10131963
wikipedia.en:Maraviroc

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from maraviroc

Phenotype where environments contain maraviroc

Phenotype modified by environments containing maraviroc

Phenotype affecting maraviroc

Human Disease Model