linezolid

Term ID

CHEBI:63607

Synonyms

• Linezolid
• N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide
• N-({(5S)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide

Definition

An organofluorine compound that consists of 1,3-oxazolidin-2-one bearing an N-3-fluoro-4-(morpholin-4-yl)phenyl group as well as an acetamidomethyl group at position 5. A synthetic antibacterial agent that inhibits bacterial protein synthesis by binding to a site on 23S ribosomal RNA of the 50S subunit and prevents further formation of a functional 70S initiation complex.

References

• cas:165800-03-3
• drugbank:DB00601
• drugcentral:1584
• kegg.compound:C08146
• kegg.drug:D00947
• lincs.smallmolecule:LSM-5750
• patent:US5688792
• patent:WO957271
• pdb-ccd:ZLD
• pubmed:21740298
• pubmed:21815204
• pubmed:21899392
• pubmed:22037854
• pubmed:22064533
• pubmed:22064542
• pubmed:22110086
• pubmed:22134348
• pubmed:22139199
• pubmed:22214776
• pubmed:22230331
• pubmed:22247123
• reaxys:7496939
• wikipedia.en:Linezolid

Ontology

ChEBI  ( EBI )