Search Ontology:
ChEBI

fludarabine phosphate

Term ID
CHEBI:63599
Synonyms
  • 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine
  • 2-Fluoro-ARA AMP
  • 2-Fluoroadenine arabinoside 5'-monophosphate
  • 2F-ara-AMP
  • 9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate
  • 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)
  • 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate
  • FAMP
  • Fludara
  • Fludarabine 5'-monophosphate
  • Fludarabine monophosphate
(all 11)
Definition
A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas.
References
(all 24)
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_functional_parent
has_role
Phenotype
Phenotype resulting from fludarabine phosphate
No data available
Phenotype where environments contain fludarabine phosphate
No data available
Phenotype modified by environments containing fludarabine phosphate
No data available
Phenotype affecting fludarabine phosphate
No data available
Human Disease Model
No data available
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