fingolimod

Term ID

CHEBI:63115

Synonyms

2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol
fingolimod
fingolimodum
FTY720

Definition

An aminodiol that consists of propane-1,3-diol having amino and 2-(4-octylphenyl)ethyl substituents at the 2-position. It is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis. A prodrug, fingolimod is phosphorylated by sphingosine kinase to active metabolite fingolimod-phosphate, a structural analogue of sphingosine 1-phosphate.

References

cas:162359-55-9
drugbank:DB08868
drugcentral:4167
kegg.drug:D10001
pubmed:11888913
pubmed:16571654
pubmed:17203219
pubmed:19940275
pubmed:21045200
pubmed:21045201
pubmed:21280229
pubmed:21394595
pubmed:21425262
pubmed:21456524
pubmed:21459808
pubmed:21652609
pubmed:21669553
pubmed:21789537
pubmed:21790210
pubmed:21838759
pubmed:21845450
pubmed:21906625
pubmed:21955849
pubmed:23073075
pubmed:23167788
pubmed:23183172
pubmed:23211038
pubmed:23223539
pubmed:23261767
pubmed:23471662
pubmed:23508350
pubmed:23518370
pubmed:23531349
pubmed:23541049
reaxys:7811195
wikipedia.en:Fingolimod

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from fingolimod

Phenotype where environments contain fingolimod

Phenotype modified by environments containing fingolimod

Phenotype affecting fingolimod

Human Disease Model