epothilone

Term ID

CHEBI:60831

Synonyms

epothilones

Definition

Any member of the class of 16-membered macrolide natural products, or their analogues, normally containing a double bond or its epoxide at positions 12-13 and bearing hydroxy groups at positions 4 and 8, methyl groups at positions 5, 5, 7, and 9, an oxo group at position 6, and a 1-(2-substituted-1,3-thiazol-4-yl)prop-1-en-2-yl substituent at position 15.

References

Patent:DE4138042
Wikipedia:Epothilone

Ontology

ChEBI ( EBI )

Relationships

is a type of: 1,3-thiazoles beta-hydroxy ketone macrolide

1,3-thiazoles beta-hydroxy ketone macrolide Show first 5 Terms
has subtype: (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-5,7,9,9-tetramethyl-14-[1-(2-methyl-4-thiazolyl)prop-1-en-2-yl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-(2-methyl-4-thiazolyl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-(2-methyl-4-thiazolyl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 9-Oxoepothilone D epothilone A ... Show All 18 Terms

(1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-5,7,9,9-tetramethyl-14-[1-(2-methyl-4-thiazolyl)prop-1-en-2-yl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-(2-methyl-4-thiazolyl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-(2-methyl-4-thiazolyl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 9-Oxoepothilone D epothilone A Epothilone A 3-alpha-D-arabinofuranoside Epothilone A9 epothilone B Epothilone B 3-alpha-D-arabinofuranoside Epothilone B10 epothilone C Epothilone C7 Epothilone C9 Epothilone C9 3-alpha-D-arabinofuranoside epothilone D Epothilone D 3-alpha-D-arabinofuranoside Epothilone E Epothilone F Show first 5 Terms
has_role: bacterial metabolite

bacterial metabolite Show first 5 Terms

Phenotype

Phenotype resulting from epothilone

Phenotype where environments contain epothilone

Phenotype modified by environments containing epothilone

Human Disease Model