fluprostenol

Term ID

CHEBI:60782

Synonyms

EINECS 255-029-3
fluprostenol
fluprostenolum
ICI 81,008
rac-(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoic acid
travoprost acid
travoprost free acid

Definition

An organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: (trifluoromethyl)benzenes hydroxy monocarboxylic acid prostaglandins Falpha

(trifluoromethyl)benzenes hydroxy monocarboxylic acid prostaglandins Falpha Show first 5 Terms
has_role: abortifacient antiglaucoma drug antihypertensive agent female contraceptive drug prostaglandin receptor agonist

abortifacient antiglaucoma drug antihypertensive agent female contraceptive drug prostaglandin receptor agonist Show first 5 Terms
inverse has_functional_parent: travoprost

travoprost Show first 5 Terms

Phenotype

Phenotype resulting from fluprostenol

Phenotype where environments contain fluprostenol

Phenotype modified by environments containing fluprostenol

Human Disease / Model Data

Citations