2-hydroxy-4-methylvaleric acid

Term ID

CHEBI:59783

Synonyms

2-hydroxy-4-methylpentanoic acid
2-hydroxyisocaproic acid
2-hydroxyisohexanoic acid
alpha-Hydroxyisocaproic acid
Leucic acid
leucinic acid

Definition

A valeric acid derivative having a hydroxy substituent at the 2-position and a methyl substituent at the 4-position; an alpha-hydroxy analogue of leucine. A bacterial metabolite, it has also been isolated from amniotic fluid, was found in a patient with dihydrolipoyl dehydrogenase deficiency and is present in the urine of patients with short bowel syndrome.

References

CAS:498-36-2
HMDB:HMDB0000665
LIPID_MAPS_instance:LMFA01050381
PMID:17439666
PMID:4018104
PMID:6467607
PMID:6688766
Reaxys:1721733

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: 2-hydroxy fatty acid branched-chain fatty acid

2-hydroxy fatty acid branched-chain fatty acid Show first 5 Terms
has subtype: (R)-2-hydroxy-4-methylpentanoic acid (S)-2-hydroxy-4-methylpentanoic acid

(R)-2-hydroxy-4-methylpentanoic acid (S)-2-hydroxy-4-methylpentanoic acid Show first 5 Terms
has_functional_parent: valeric acid

valeric acid Show first 5 Terms
has_role: metabolite

metabolite Show first 5 Terms
inverse is_conjugate_base_of: 2-hydroxy-4-methylvalerate

2-hydroxy-4-methylvalerate Show first 5 Terms
is_conjugate_acid_of: 2-hydroxy-4-methylvalerate

2-hydroxy-4-methylvalerate Show first 5 Terms

Phenotype

Phenotype resulting from 2-hydroxy-4-methylvaleric acid

Phenotype where environments contain 2-hydroxy-4-methylvaleric acid

Phenotype modified by environments containing 2-hydroxy-4-methylvaleric acid

Human Disease / Model Data

Citations