polymyxin

Term ID

CHEBI:59062

Synonyms

polymixin
polymycin
polymyxins

Definition

Polymyxins are antibiotics with a general structure consisting of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. Polymyxins are produced by the Gram-positive bacterium Bacillus polymyxa and are selectively toxic for Gram-negative bacteria.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: heterodetic cyclic peptide lipopeptide

heterodetic cyclic peptide lipopeptide Show first 5 Terms
has subtype: colistimethate colistimethate A colistimethate B colistimethate sodium colistin ... Show All 11 Terms

colistimethate colistimethate A colistimethate B colistimethate sodium colistin colistin A colistin A sodium methanesulfonate colistin B colistin B sodium methanesulfonate polymyxin B1 polymyxin B2 Show first 5 Terms
has_role: antibacterial agent antimicrobial agent

antibacterial agent antimicrobial agent Show first 5 Terms

Phenotype

Phenotype resulting from polymyxin

Phenotype where environments contain polymyxin

Phenotype modified by environments containing polymyxin

Human Disease / Model Data

Citations