felodipine

Term ID

CHEBI:585948

Synonyms

• (+-)-ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
• 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate
• 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
• ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• felodipina
• felodipine
• felodipinum

Definition

The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.

References

• cas:72509-76-3
• drugbank:DB01023
• drugcentral:1142
• kegg.drug:D00319
• lincs.smallmolecule:LSM-1447
• patent:EP7293
• patent:US4264611
• pdb-ccd:225
• pubmed:18457386
• reaxys:4331472
• wikipedia.en:Felodipine

Ontology

ChEBI  ( EBI )

Resources

CTD