Search Ontology:
ChEBI

cladribine

Term ID
CHEBI:567361
Synonyms
  • (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
  • 2-CdA
  • 2-chloro-2'-deoxy-beta-adenosine
  • 2-chloro-2'-deoxyadenosine
  • 2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine
  • 2-chloro-deoxyadenosine
  • 2-chlorodeoxyadenosine
  • 2ClAdo
  • cladribina
  • Cladribine
  • cladribinum
  • CldAdo
Definition
2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from cladribine
Phenotype where environments contain cladribine
Phenotype modified by environments containing cladribine
Human Disease / Model Data
Citations
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