bortezomib

Term ID

CHEBI:52717

Synonyms

• [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid
• bortezomib
• N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
• N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
• PS 341
• PS-341
• Velcade

Definition

L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N^α by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.

References

• cas:179324-69-7
• drugbank:DB00188
• drugcentral:391
• kegg.drug:D03150
• lincs.smallmolecule:LSM-6281
• pdb-ccd:BO2
• pubmed:18484921
• pubmed:18980173
• pubmed:21504411
• pubmed:21865767
• reaxys:8723817
• wikipedia.en:Bortezomib

Ontology

ChEBI  ( EBI )