dutasteride

Term ID

CHEBI:521033

Synonyms

(5alpha,17beta)-N-(2,5-bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide
N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide

Definition

An aza-steroid that is inasteride in which the tert-butyl group is replaced by a 2,5-bis(trifluoromethyl)phenyl group. A synthetic 4-azasteroid, dutasteride is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5alpha-reductase, an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone. Dutasteride is used for the treatment of symptomatic benign prostatic hyperplasia in men with an enlarged prostate gland.

References

Beilstein:7401530
CAS:164656-23-9
DrugBank:DB01126
Drug_Central:973
KEGG:D03820
Patent:WO9507927
Wikipedia:Dutasteride

Ontology

ChEBI ( EBI )

Relationships

is a type of: (trifluoromethyl)benzenes aza-steroid delta-lactam

(trifluoromethyl)benzenes aza-steroid delta-lactam Show first 5 Terms
has_parent_hydride: 5alpha-androstane

5alpha-androstane Show first 5 Terms
has_role: antihyperplasia drug EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor

antihyperplasia drug EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from dutasteride

Phenotype where environments contain dutasteride

Phenotype modified by environments containing dutasteride

Human Disease / Model Data

Citations