doxycycline

Term ID

CHEBI:50845

Synonyms

• (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE
• 5-hydroxy-alpha-6-deoxytetracycline
• 6alpha-deoxy-5-oxytetracycline
• doxiciclina
• Doxycyclin
• Doxycycline
• doxycycline (anhydrous)
• doxycyclinum
• Jenacyclin
• Supracyclin
• Vibramycin

Definition

Tetracycline in which the 5β-hydrogen is replaced by a hydroxy group, while the 6α-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis.

References

• cas:564-25-0
• chemspider:10469369
• drugbank:DB00254
• drugcentral:961
• hmdb:HMDB0014399
• kegg.compound:C06973
• kegg.drug:D07876
• knapsack:C00017127
• lipidmaps:LMPK07000001
• metacyc.compound:CPD-19256
• patent:US3019260
• patent:US3200149
• pdb-ccd:DXT
• pmc:PMC8464303
• pmc:PMC8466018
• pubmed:11477376
• pubmed:11850258
• pubmed:11891205
• pubmed:1650428
• pubmed:16651635
• pubmed:19630297
• pubmed:23698443
• pubmed:24134630
• pubmed:34128838
• pubmed:34228348
• pubmed:34318509
• pubmed:34338231
• pubmed:34355683
• pubmed:34551605
• pubmed:34577552
• reaxys:3041790
• vsdb:1840
• wikipedia.en:Doxycycline

Ontology

ChEBI  ( EBI )

Resources

CTD