Search Ontology:
ChEBI
EC 5.99.1.2 (DNA topoisomerase) inhibitor
- Term ID
- CHEBI:50276
- Synonyms
-
- DNA topoisomerase inhibitor
- DNA topoisomerase inhibitors
- EC 5.99.1.2 (DNA topoisomerase) inhibitors
- EC 5.99.1.2 (topoisomerase I) inhibitor
- EC 5.99.1.2 (topoisomerase I) inhibitors
- EC 5.99.1.2 inhibitor
- EC 5.99.1.2 inhibitors
- topoisomerase I (EC 5.99.1.2) inhibitor
- topoisomerase I (EC 5.99.1.2) inhibitors
- topoisomerase I inhibitor
- topoisomerase I inhibitors
- type I DNA topoisomerase inhibitor
- type I DNA topoisomerase inhibitors
- Definition
- A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
- References
- Ontology
- ChEBI ( EBI )
- is a type of
-
- inverse has_role
Show first 5 Terms
Show All 30 Terms
Phenotype
Phenotype resulting from EC 5.99.1.2 (DNA topoisomerase) inhibitor
Phenotype where environments contain EC 5.99.1.2 (DNA topoisomerase) inhibitor
Phenotype modified by environments containing EC 5.99.1.2 (DNA topoisomerase) inhibitor
Human Disease Model