brexanolone

Term ID

CHEBI:50169

Synonyms

(3alpha,5alpha)-3-hydroxypregnan-20-one
3-alpha-hydroxy-5-alpha-pregnan-20-one
3alpha,5alpha-tetrahydroprogesterone
3alpha,5alpha-THP
3alpha-hydroxy-5alpha-dihydroprogesterone
3alpha-hydroxy-5alpha-pregnan-20-one
3alpha-OH DHP
5alpha-pregnan-3alpha-ol-20-one
allopregnan-3alpha-ol-20-one
allopregnanolone
allotetrahydroprogesterone
brexanolona
brexanolone
brexanolonum
SAGE-547
SGE-102
Zulresso

Definition

A 3-hydroxy-5α-pregnan-20-one in which the hydroxy group at position 3 has α-configuration. It is a metabolite of the sex hormone progesterone and used for the treatment of postpartum depression in women.

References

beilstein:3211363
cas:516-54-1
drugbank:DB11859
foodb.food:FDB022630
hmdb:HMDB0001449
kegg.compound:C13712
kegg.drug:D11149
lincs.smallmolecule:LSM-19998
lipidmaps:LMST02030130
pubmed:10625505
pubmed:11739473
pubmed:19290593
pubmed:28370307
pubmed:28619476
pubmed:28666923
pubmed:28779545
pubmed:29453777
pubmed:29636114
pubmed:30177236
pubmed:30362283
pubmed:30481569
pubmed:30701996
pubmed:9501247
wikipedia.en:Allopregnanolone

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from brexanolone

Phenotype where environments contain brexanolone

Phenotype modified by environments containing brexanolone

Phenotype affecting brexanolone

Human Disease Model