etacrynic acid

Term ID

CHEBI:4876

Synonyms

• (2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy)acetic acid
• [2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
• acide etacrynique
• acido etacrinico
• acidum etacrynicum
• Crinuryl
• Edecril
• Edecrina
• Endecril
• Etacrinic acid
• etacrynic acid
• Ethacrynate
• ethacrynic acid
• Hidromedin
• Hydromedin
• Methylenebutyrylphenoxyacetic acid
• Mingit
• Otacril
• Reomax
• Taladren
• Uregit

Definition

An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.

References

• cas:58-54-8
• drugbank:DB00903
• drugcentral:1071
• hmdb:HMDB0015039
• kegg.drug:D00313
• lincs.smallmolecule:LSM-3420
• pdb-ccd:EAA
• pubmed:7932170
• reaxys:1915060
• wikipedia.en:Etacrynic_acid

Ontology

ChEBI  ( EBI )

Resources

CTD