esmolol

Term ID

CHEBI:4856

Synonyms

(+-)-esmolol
(+-)-methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate
3-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-propionic acid methyl ester
esmolol
esmololum
Methyl 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate
methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate
rac-methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate

Definition

A racemate comprising equimolar amounts of (R)- and (S)-esmolol. A cardioselective and short-acting β₁ receptor blocker with rapid onset but lacking intrinsic sympathomimetic and membrane-stabilising properties, it is used as the hydrochloride salt in the management of supraventricular arrhythmias, and for the control of hypertension and tachycardia during surgery. While the S enantiomer possesses all of the heart rate control, both enantiomers contribute to lowering blood pressure.

References

cas:103598-03-4
cas:81147-92-4
drugbank:DB00187
hmdb:HMDB0014333
kegg.compound:C06980
kegg.drug:D07916
patent:EP41491
patent:EP53435
patent:US4593119
pubmed:16118074
pubmed:24500140
pubmed:25105423
pubmed:25575405
pubmed:26073350
pubmed:26137757
pubmed:26316443
reaxys:5287174
wikipedia.en:Esmolol

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from esmolol

Phenotype where environments contain esmolol

Phenotype modified by environments containing esmolol

Phenotype affecting esmolol

Human Disease Model