salinosporamide A

Term ID

CHEBI:48045

Synonyms

(-)-salinosporamide A
(1R,4R,5S)-4-(2-chloroethyl)-1-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
marizomib
marizomibum
ML 858
NPI 0052
NPI-0052

Definition

A salinosporamide in which the core (1R)-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione skeleton is substituted at positions 1, 4, and 5 by (1S)-cyclohex-2-en-1-yl(hydroxy)methyl, 2-chloroethyl, and methyl groups, respectively (the 1R,4R,5S diastereoisomer). A potent proteasome inhibitor, it has attracted interest for potential use in the treatment of various cancers.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: beta-lactone gamma-lactam organic heterobicyclic compound organochlorine compound salinosporamide

beta-lactone gamma-lactam organic heterobicyclic compound organochlorine compound salinosporamide Show first 5 Terms
has_role: antineoplastic agent proteasome inhibitor

antineoplastic agent proteasome inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from salinosporamide A

Phenotype where environments contain salinosporamide A

Phenotype modified by environments containing salinosporamide A

Human Disease / Model Data

Citations