Search Ontology:
ChEBI
salinosporamide A
- Term ID
- CHEBI:48045
- Synonyms
-
- (-)-salinosporamide A
- (1R,4R,5S)-4-(2-chloroethyl)-1-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
- marizomib
- marizomibum
- ML 858
- NPI 0052
- NPI-0052
- Definition
- A salinosporamide in which the core (1R)-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione skeleton is substituted at positions 1, 4, and 5 by (1S)-cyclohex-2-en-1-yl(hydroxy)methyl, 2-chloroethyl, and methyl groups, respectively (the 1R,4R,5S diastereoisomer). A potent proteasome inhibitor, it has attracted interest for potential use in the treatment of various cancers.
- References
-
- cas:437742-34-2
- kegg.drug:D09640
- knapsack:C00040190
- metacyc.compound:CPD-12674
- pubmed:12548698
- pubmed:15916417
- pubmed:17121896
- pubmed:17497868
- pubmed:17609425
- pubmed:18939815
- pubmed:19022674
- pubmed:19133779
- pubmed:20479958
- pubmed:21058386
- pubmed:21247382
- pubmed:21303921
- pubmed:21591679
- pubmed:21824108
- pubmed:22195555
- pubmed:22500807
- pubmed:24737138
- pubmed:25068416
- reaxys:9349224
- wikipedia.en:Salinosporamide_A
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from salinosporamide A
Phenotype where environments contain salinosporamide A
Phenotype modified by environments containing salinosporamide A
Phenotype affecting salinosporamide A
Human Disease Model