encainide

Term ID

CHEBI:4788

Synonyms

• (+-)-2'-[2-(1-methyl-2-piperidyl)ethyl]-p-anisanilide
• (+-)-4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)benzamide
• 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide
• 4-Methoxy-N-{2-[2-(1-methyl-piperidin-2-yl)-ethyl]-phenyl}-benzamide
• 4-methoxy-N-{2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl}benzamide
• encainida
• Encainide
• encainidum

Definition

4-Methoxy-N-phenylbenzamide in which the hydrogen at the 2 position of the phenyl group is substituted by a 2-(1-methylpiperidin-2-yl)ethyl group. A class Ic antiarrhythmic, the hydrochloride was used for the treatment of severe or life-threatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market.

References

• Beilstein:497572
• CAS:66778-36-7
• DrugBank:DB01228
• Drug_Central:1007
• KEGG:C06978
• KEGG:D07894
• Patent:DE2210154
• Patent:US3931195

Ontology

ChEBI  ( EBI )

Resources

CTD