emedastine

Term ID

CHEBI:4779

Synonyms

• 1-(2-Ethoxy-ethyl)-2-(4-methyl-[1,4]diazepan-1-yl)-1H-benzoimidazole
• 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)-1H-benzimidazole
• 1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzimidazole
• 1-[2-(ethoxy)ethyl]-2-(4-methyl-1-homopiperazinyl)benzimidazole
• emedastina
• EMEDASTINE
• emedastinum

Definition

1-Methyl-1,4-diazepane in which the hydrogen attached to the nitrogen at position 4 is substituted by a 1-(2-ethoxyethyl)-1H-benzimidazol-2-yl group. A relatively selective histamine H₁ antagonist, it is used as the difumatate salt for allergic rhinitis, urticaria, and pruritic skin disorders, and in eyedrops for the symptomatic relief of allergic conjuntivitis.

References

• beilstein:6068161
• cas:87233-61-2
• drugbank:DB01084
• drugcentral:999
• kegg.compound:C07785
• kegg.drug:D07890
• lincs.smallmolecule:LSM-5331
• patent:US4430343
• wikipedia.en:Emedastine

Ontology

ChEBI  ( EBI )

Resources

CTD