clomipramine

Term ID

CHEBI:47780

Synonyms

• 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine
• 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
• 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE
• 3-chloroimipramine
• chlorimipramine
• Clomipramine
• G 34586
• monochlorimipramine

Definition

A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.

References

• cas:303-49-1
• drugbank:DB01242
• drugcentral:701
• kegg.compound:C06918
• kegg.drug:D07727
• lincs.smallmolecule:LSM-3171
• patent:CH371799
• patent:US3467650
• pdb-ccd:CXX
• pubmed:12007764
• pubmed:12084414
• pubmed:16085036
• pubmed:17471183
• pubmed:19747949
• pubmed:19810911
• reaxys:1323477
• wikipedia.en:Clomipramine

Ontology

ChEBI  ( EBI )

Resources

CTD