licofelone

Term ID

CHEBI:47532

Synonyms

6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic acid
[2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
licofelona
licofelone
licofelonum
ML 3000
ML-3000
ML3000

Definition

A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine substituted by methyl, methyl, carboxymethyl, 4-chlorophenyl, and phenyl groups at positions 2, 2, 5, 6, and 7, respectively. It is a dual inhibitor of cyclooxygenase isoforms and 5-lipoxygenase and is under development for treatment of osteoarthritis.

References

cas:156897-06-2
drugbank:DB04725
hmdb:HMDB0254080
patent:CZ20080621
pdb-ccd:LCF
pubmed:11671883
pubmed:12099169
pubmed:12136904
pubmed:15028114
pubmed:16448396
pubmed:17695530
pubmed:18268076
pubmed:18550688
pubmed:21681808
pubmed:21885812
pubmed:29163396
pubmed:29789101
pubmed:29891506
pubmed:30709010
pubmed:31471100
pubmed:31562745
pubmed:32949599
pubmed:33852076
pubmed:34395219
pubmed:34517113
pubmed:35923080
pubmed:37233919
pubmed:38173598
pubmed:39062118
pubmed:39395583
pubmed:9514627
wikipedia.en:Licofelone

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from licofelone

Phenotype where environments contain licofelone

Phenotype modified by environments containing licofelone

Phenotype affecting licofelone

Human Disease Model