Search Ontology:
ChEBI
doxercalciferol
- Term ID
- CHEBI:4712
- Synonyms
-
- (1S,3R,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraene-1,3-diol
- 1-alpha-hydroxyvitamin D2
- 1alpha-hydroxyergocalciferol
- 1alpha-hydroxyvitamin D2
- doxercalciferol
- doxercalciferolum
- Hectorol
- Definition
- A hydroxy seco-steroid and synthetic vitamin D2 analogue that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. It is used to treat secondary hyperparathyroidism, a condition in which the body produces excess parathyroid hormone (PTH; a natural substance needed to control the amount of calcium in the blood) in certain people with chronic kidney disease.
- References
-
- cas:54573-75-0
- drugbank:DB06410
- drugcentral:957
- kegg.compound:C08211
- kegg.drug:D01009
- pdb-ccd:V2H
- pubmed:12227689
- pubmed:12834181
- pubmed:17603751
- pubmed:21155068
- pubmed:21849802
- pubmed:22123370
- pubmed:23780943
- pubmed:25774916
- pubmed:28586017
- wikipedia.en:Doxercalciferol
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from doxercalciferol
Phenotype where environments contain doxercalciferol
Phenotype modified by environments containing doxercalciferol
Phenotype affecting doxercalciferol
Human Disease Model