dorzolamide

Term ID

CHEBI:4702

Synonyms

• (4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
• (4S,6S)-4-ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide
• (4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
• (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE
• 4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide
• 4-ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda6-thieno[2,3-b]thiopyran-2-sulfonic acid amide
• 4S,6S-dorzolamide
• Dorzolamide

Definition

5,6-Dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide in which hydrogens at the 4 and 6 positions are substituted by ethylamino and methyl groups, respectively (4S, trans-configuration). A carbonic anhydrase inhibitor, it is used as the hydrochloride in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.

References

• beilstein:5910880
• cas:120279-96-1
• drugbank:DB00869
• drugcentral:949
• kegg.compound:C06969
• kegg.drug:D07871
• lincs.smallmolecule:LSM-5597
• patent:EP296879
• patent:US4797413
• pdb-ccd:ETS
• pubmed:10762051
• pubmed:11229775
• pubmed:11425561
• pubmed:11906288
• pubmed:14611846
• pubmed:14684332
• wikipedia.en:Dorzolamide

Ontology

ChEBI  ( EBI )