imatinib

Term ID

CHEBI:45783

Synonyms

4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE
4-[(4-methylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide
alpha-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-toluidide
imatinib
STI 571

Definition

A benzamide obtained by formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary aromatic amino group of 4-methyl-N³-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine. Used (as its mesylate salt) for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.

References

beilstein:7671333
cas:152459-95-5
drugbank:DB00619
drugcentral:1423
hmdb:HMDB0014757
kegg.drug:D08066
lincs.smallmolecule:LSM-1023
patent:EP564409
patent:US5521184
pdb-ccd:STI
pubmed:14660054
pubmed:14715630
pubmed:15073101
pubmed:15170967
pubmed:15722647
pubmed:15794712
pubmed:15966213
pubmed:16122278
pubmed:16826359
pubmed:16983347
pubmed:17190842
pubmed:17410337
pubmed:17457302
pubmed:17717205
pubmed:18193246
pubmed:18216472
pubmed:18337118
pubmed:18344535
pubmed:18376233
pubmed:18407734
pubmed:18420270
pubmed:18423008
pubmed:18548219
pubmed:18623899
pubmed:18780518
pubmed:18809244
pubmed:19020005
pubmed:19052981
pubmed:19077095
pubmed:19097599
pubmed:19182535
pubmed:19242505
pubmed:19415889
pubmed:19527930
pubmed:19591692
pubmed:19693287
pubmed:19749465
pubmed:19810774
pubmed:19853594
pubmed:19920908
pubmed:22891806
pubmed:23075630
pubmed:23183914
pubmed:23313020
pubmed:23394269
pubmed:23480638
pubmed:23503753
pubmed:23536338
pubmed:23574742
pubmed:23580311
pubmed:23587588
reaxys:7671333
wikipedia.en:Imatinib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from imatinib

Phenotype where environments contain imatinib

Phenotype modified by environments containing imatinib

Phenotype affecting imatinib

Human Disease Model