vorinostat

Term ID

CHEBI:45716

Synonyms

• N-hydroxy-N'-phenyloctanediamide
• octanedioic acid hydroxyamide phenylamide
• SAHA
• SHH
• Suberanilohydroxamic acid
• suberoylanilide hydroxamic acid
• vorinostat
• vorinostatum
• Zolinza

Definition

A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).

References

• cas:149647-78-9
• drugbank:DB02546
• drugcentral:4124
• hmdb:HMDB0015568
• kegg.drug:D06320
• lincs.smallmolecule:LSM-3828
• patent:CN102641261
• patent:KR20110045493
• patent:NZ592686
• patent:US2011039937
• patent:WO2008106524
• pdb-ccd:SHH
• pubmed:21657958
• pubmed:22887890
• pubmed:23320102
• pubmed:23348693
• pubmed:23708756
• pubmed:23758082
• pubmed:23820962
• pubmed:23864881
• reaxys:7213017
• wikipedia.en:Vorinostat

Ontology

ChEBI  ( EBI )