ritonavir

Term ID

CHEBI:45409

Synonyms

• N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N(2)-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
• ritonavir

Definition

An L-valine derivative that is L-valinamide in which α-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP₃A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.

References

• cas:155213-67-5
• drugcentral:2391
• hmdb:HMDB0014646
• kegg.compound:C07240
• kegg.drug:D00427
• lincs.smallmolecule:LSM-5623
• pdb-ccd:RIT
• pubmed:11363086
• pubmed:11363184
• pubmed:11363300
• pubmed:11363329
• pubmed:11363397
• pubmed:11363517
• pubmed:11996889
• pubmed:24202050
• pubmed:38578027
• pubmed:38609668
• pubmed:8568292
• pubmed:9140265
• pubmed:9278209
• pubmed:9585800
• reaxys:768009
• wikipedia.en:Ritonavir

Ontology

ChEBI  ( EBI )