Search Ontology:
ChEBI

5-(2-ethoxyethyl)-5-[4-(4-fluorophenoxy)phenoxy]barbituric acid

Term ID
CHEBI:45030
Synonyms
  • 5-(2-ethoxyethyl)-5-[4-(4-fluorophenoxy)phenoxy]pyrimidine-2,4,6(1H,3H,5H)-trione
Definition
A member of the class of barbiturates that is barbituric acid in which the hydrogens at position 5 are replaced by 2-ethoxyethyl and 4-(4-fluorophenoxy)phenoxy groups. It is a potent and selective inhibitor of matrix MMP-13 (metalloproteinase-13, collagenase 3).
References
  • beilstein:9950446
  • drugbank:DB08388
  • pdb-ccd:PFD
  • pubmed:15780611
  • reaxys:9950446
Ontology
ChEBI  ( EBI )
Relationships
Phenotype
Phenotype resulting from 5-(2-ethoxyethyl)-5-[4-(4-fluorophenoxy)phenoxy]barbituric acid
Phenotype where environments contain 5-(2-ethoxyethyl)-5-[4-(4-fluorophenoxy)phenoxy]barbituric acid
Phenotype modified by environments containing 5-(2-ethoxyethyl)-5-[4-(4-fluorophenoxy)phenoxy]barbituric acid
Phenotype affecting 5-(2-ethoxyethyl)-5-[4-(4-fluorophenoxy)phenoxy]barbituric acid
Human Disease Model
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