diazoxide

Term ID

CHEBI:4495

Synonyms

• 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
• Diazossido
• diazoxide
• diazoxido
• diazoxidum
• Eudemine

Definition

A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the β- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.

References

• cas:364-98-7
• drugbank:DB01119
• drugcentral:854
• hmdb:HMDB0015251
• kegg.compound:C06949
• kegg.drug:D00294
• lincs.smallmolecule:LSM-3639
• patent:DE723278
• patent:US2986573
• patent:US3345365
• pubmed:11014217
• pubmed:12039709
• pubmed:15319354
• pubmed:16740260
• pubmed:16777075
• pubmed:18191077
• pubmed:20828743
• pubmed:20950601
• pubmed:21538163
• pubmed:21693179
• pubmed:22047130
• pubmed:29438107
• reaxys:523907
• wikipedia.en:Diazoxide

Ontology

ChEBI  ( EBI )

Resources

CTD