(S)-fenfluramine

Term ID

CHEBI:439329

Synonyms

(+)-fenfluramine
(2S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
(S)-fenfluramine
(S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
d-N-ethyl-alpha-methyl-m-trifluoromethylphenethylamine
dexfenfluramina
dexfenfluramine
dexfenfluraminum
dextrofenfluramine

Definition

The S-enantiomer of fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike fenfluramine it does not possess catecholamine agonist activity. It was formerly given by mouth as the hydrochloride in the treatment of obesity, but, like fenfluramine, was withdrawn wolrdwide following reports of valvular heart defects.

References

Beilstein:4783710
CAS:3239-44-9
DrugBank:DB01191
Drug_Central:832
KEGG:D07805
LINCS:LSM-5685
PMID:16257207
Patent:US3198834

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: fenfluramine

fenfluramine Show first 5 Terms
has_role: appetite depressant serotonergic agonist serotonin uptake inhibitor

appetite depressant serotonergic agonist serotonin uptake inhibitor Show first 5 Terms
inverse has_part: (S)-fenfluramine hydrochloride

(S)-fenfluramine hydrochloride Show first 5 Terms
inverse is_enantiomer_of: (R)-fenfluramine

(R)-fenfluramine Show first 5 Terms
is_enantiomer_of: (R)-fenfluramine

(R)-fenfluramine Show first 5 Terms

Phenotype

Phenotype resulting from (S)-fenfluramine

Phenotype where environments contain (S)-fenfluramine

Phenotype modified by environments containing (S)-fenfluramine

Human Disease Model