methyllycaconitine

Term ID

CHEBI:43931

Synonyms

(1alpha,6beta,14alpha,16beta)-20-ethyl-1,6,14,16-tetramethoxy-4-[[[2-[(3S)-3-methyl-2,5-dioxo-1-pyrrolidinyl]benzoyl]oxy]methyl]aconitane-7,8-diol
(20-ethyl-7,8-dihydroxy-1alpha,6beta,14alpha,16beta-tetramethoxyaconitan-4-yl)methyl 2-[(3S)-3-methyl-2,5-dioxopyrrolidin-1-yl]benzoate
delartine
MLA

Definition

A naturally occurring norditerpenoid alkaloid that is isolated from several species of Delphinium. It is a highly potent and selective antagonist of α7 nicotinic acetylcholine receptors (IC₅₀ = 2 nM).

References

cas:21019-30-7
chemspider:4450894
kegg.compound:C08699
knapsack:C00001655
lincs.smallmolecule:LSM-1457
pdb-ccd:MLK
pubmed:1569927
pubmed:16193063
pubmed:17178240
pubmed:18539831
pubmed:19098233
pubmed:19566479
pubmed:20377277
pubmed:21337354
pubmed:21521823
pubmed:21554871
pubmed:22009746
pubmed:22609758
pubmed:22778816
pubmed:22884467
pubmed:23296980
pubmed:23702881
pubmed:23893416
pubmed:25282151
pubmed:25360664
pubmed:25505596
pubmed:31176021
pubmed:31898891
pubmed:32044666
pubmed:3338564
pubmed:33657437
pubmed:33691518
pubmed:34443654
pubmed:34798380
pubmed:37096031
pubmed:38974115
wikipedia.en:Methyllycaconitine

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from methyllycaconitine

Phenotype where environments contain methyllycaconitine

Phenotype modified by environments containing methyllycaconitine

Phenotype affecting methyllycaconitine

Human Disease Model