fasudil

Term ID

CHEBI:43871

Synonyms

1-(5-isoquinolinesulfonyl)homopiperazine
5-(1,4-diazepan-1-ylsulfonyl)isoquinoline
5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]isoquinoline
AT 877
AT-877
fasudil
fasudilum
HA 1077
HA-1077
HA1077
hexahydro-1-(5-isoquinolinesulfonyl)-1H-1,4-diazepine
hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine
ZK-258594

Definition

An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.

References

cas:103745-39-7
chemspider:3426
drugbank:DB08162
drugcentral:1132
hmdb:HMDB0252175
kegg.drug:D07941
lincs.smallmolecule:LSM-3715
pdb-ccd:M77
pubmed:22363408
pubmed:31670380
pubmed:31894538
pubmed:32076619
pubmed:32192772
pubmed:32396545
pubmed:32462797
pubmed:32650141
pubmed:32685556
pubmed:32727014
pubmed:32770034
pubmed:33222274
pubmed:33341946
pubmed:33357780
pubmed:33433459
pubmed:33436060
pubmed:33527868
pubmed:33832886
pubmed:33838256
pubmed:33907042
pubmed:34078832
pubmed:34156163
pubmed:34239271
pubmed:34359853
pubmed:34384329
pubmed:34542824
pubmed:34557101
pubmed:34558416
wikipedia.en:Fasudil

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from fasudil

Phenotype where environments contain fasudil

Phenotype modified by environments containing fasudil

Phenotype affecting fasudil

Human Disease Model