obeticholic acid

Term ID

CHEBI:43602

Synonyms

(3alpha,5beta,6alpha,7alpha)-6-ethyl-3,7-dihydroxycholan-24-oic acid
6-ECDCA
6-Ethyl-CDCA
6-Ethylchenodeoxycholic acid
6alpha-ethyl-3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid
6alpha-Ethyl-chenodeoxycholic acid
6alpha-ethylchenodeoxycholic acid
INT 747
INT-747
INT747
obeticholic acid
Ocaliva

Definition

A dihydroxy-5β-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6α-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatment of primary biliary cholangitis.

References

cas:459789-99-2
drugcentral:5155
kegg.compound:C15636
kegg.drug:D09360
pdb-ccd:CHC
pubmed:22406511
pubmed:23593273
pubmed:24382005
pubmed:24623154
pubmed:25329562
pubmed:25421586
pubmed:25468160
pubmed:25500425
pubmed:25592258
pubmed:25726736
pubmed:25753820
pubmed:25864227
pubmed:26136168
pubmed:26169860
pubmed:26169861
pubmed:26169862
pubmed:26549695
pubmed:26723896
pubmed:26811456
pubmed:26812075
pubmed:27109453
pubmed:27406083
pubmed:27425465
pubmed:27468093
pubmed:27475255
reaxys:9238543
wikipedia.en:Obeticholic_acid

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from obeticholic acid

Phenotype where environments contain obeticholic acid

Phenotype modified by environments containing obeticholic acid

Phenotype affecting obeticholic acid

Human Disease Model