desferrioxamine B

Term ID

CHEBI:4356

Synonyms

Deferoxamin
deferoxamina
deferoxamine
deferoxaminum
Deferrioxamine
deferrioxamine B
Desferrioxamine
desferrioxamine-B
DFO
DFOB
N'-{5-[acetyl(hydroxy)amino]pentyl}-N-(5-{4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanamido}pentyl)-N-hydroxybutanediamide
N(4)-{5-[acetyl(hydroxy)amino]pentyl}-N(1)-(5-{4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanamido}pentyl)-N(1)-hydroxybutanediamide

Definition

An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N¹-(5-aminopentyl)-N¹-hydroxy-N⁴-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.

References

beilstein:2514118
cas:70-51-9
chemspider:2867
drugbank:DB00746
drugcentral:792
hmdb:HMDB0014884
kegg.compound:C06940
kegg.drug:D03670
lincs.smallmolecule:LSM-6541
lipidmaps:LMFA08020169
patent:BE609053
pubmed:11239825
pubmed:18536609
pubmed:28156129
pubmed:28285915
pubmed:28318697
pubmed:28455567
pubmed:29182270
pubmed:30701380
pubmed:31035197
pubmed:31229836
pubmed:31846315
pubmed:32039778
pubmed:32572744
pubmed:32734456
pubmed:32856363
pubmed:33784308
wikipedia.en:Deferoxamine

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from desferrioxamine B

Phenotype where environments contain desferrioxamine B

Phenotype modified by environments containing desferrioxamine B

Phenotype affecting desferrioxamine B

Human Disease Model