dalfopristin

Term ID

CHEBI:4309

Synonyms

• (3R,4R,5E,10E,12E,14S,26R,26aS)-26-{[2-(diethylamino)ethyl]sulfonyl}-14-hydroxy-4,12-dimethyl-3-(propan-2-yl)-8,9,14,15,24,25,26,26a-octahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone
• dalfopristin
• dalfopristina
• dalfopristine
• dalfopristinum
• RP 54476
• RP-54476
• RP54476

Definition

A macrolide that is pristinamycin IIA in which the double bond between positions 26 and 26a of the pyrroline ring has been reduced and position 26R carries a [2-(diethylamino)ethyl]sulfonyl group. It is a semi-synthetic streptogramin antibiotic and often used as a mixture with quinupristin for the treatment of vancomycin-resistant Enterococcus faecium.

References

• cas:112362-50-2
• drugbank:DB01764
• drugcentral:778
• hmdb:HMDB0015566
• kegg.compound:C08033
• kegg.drug:D00853
• pdb-ccd:DOL
• pubmed:11985218
• pubmed:12771141
• pubmed:1328138
• pubmed:15059283
• pubmed:17563376
• pubmed:18056275
• pubmed:19409762
• pubmed:21453475
• pubmed:23044949
• pubmed:23924572
• pubmed:24827721
• pubmed:24957822
• pubmed:25218154
• pubmed:25566405
• pubmed:27158605
• pubmed:27528592
• pubmed:27689100
• pubmed:27769188
• pubmed:29478197
• pubmed:30169641
• pubmed:32321574
• pubmed:32812867
• pubmed:7843184
• pubmed:9653958
• wikipedia.en:Dalfopristin

Ontology

ChEBI  ( EBI )