dalfopristin

Term ID

CHEBI:4309

Synonyms

• (3R,4R,5E,10E,12E,14S,26R,26aS)-26-{[2-(diethylamino)ethyl]sulfonyl}-14-hydroxy-4,12-dimethyl-3-(propan-2-yl)-8,9,14,15,24,25,26,26a-octahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone
• dalfopristin
• dalfopristina
• dalfopristine
• dalfopristinum
• RP 54476
• RP-54476
• RP54476

Definition

A macrolide that is pristinamycin IIA in which the double bond between positions 26 and 26a of the pyrroline ring has been reduced and position 26R carries a [2-(diethylamino)ethyl]sulfonyl group. It is a semi-synthetic streptogramin antibiotic and often used as a mixture with quinupristin for the treatment of vancomycin-resistant Enterococcus faecium.

References

• CAS:112362-50-2
• DrugBank:DB01764
• Drug_Central:778
• HMDB:HMDB0015566
• KEGG:C08033
• KEGG:D00853
• PDBeChem:DOL
• PMID:11985218
• PMID:12771141
• PMID:1328138
• PMID:15059283
• PMID:17563376
• PMID:18056275
• PMID:19409762
• PMID:21453475
• PMID:23044949
• PMID:23924572
• PMID:24827721
• PMID:24957822
• PMID:25218154
• PMID:25566405
• PMID:27158605
• PMID:27528592
• PMID:27689100
• PMID:27769188
• PMID:29478197
• PMID:30169641
• PMID:32321574
• PMID:32812867
• PMID:7843184
• PMID:9653958
• Wikipedia:Dalfopristin

Ontology

ChEBI  ( EBI )