Search Ontology:
ChEBI
4-hydroxyphenyl retinamide
- Term ID
- CHEBI:42588
- Synonyms
-
- 15-[(4-hydroxyphenyl)amino]retinal
- 4-HPR
- 4-hydroxy(phenyl)retinamide
- all-trans-4'-Hydroxyretinanilide
- fenretinida
- fenretinide
- fenretinidum
- N-(4-HYDROXYPHENYL)ALL-TRANS RETINAMIDE
- N-(4-Hydroxyphenyl)retinamide
- Definition
- A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
- References
-
- cas:65646-68-6
- drugbank:DB05076
- kegg.drug:D04162
- pdb-ccd:FEN
- pubmed:20878269
- pubmed:20978709
- pubmed:21241664
- pubmed:21319187
- pubmed:21674264
- pubmed:21964808
- pubmed:22094120
- pubmed:22162577
- pubmed:22183330
- pubmed:22221098
- pubmed:22280430
- pubmed:22323082
- pubmed:22350416
- pubmed:22382323
- pubmed:22387538
- reaxys:5769490
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
Phenotype
Phenotype resulting from 4-hydroxyphenyl retinamide
Phenotype where environments contain 4-hydroxyphenyl retinamide
Phenotype modified by environments containing 4-hydroxyphenyl retinamide
Phenotype affecting 4-hydroxyphenyl retinamide
Human Disease Model