Search Ontology:
ChEBI

3-(5-fluorouracil-1-yl)-L-alanine

Term ID
CHEBI:42549
Synonyms
  • (2S)-2-amino-3-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid
  • (S)-(-)-5-fluorowillardiine
  • (S)-alpha-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimmidinepropanoic acid
  • (S)-F-Willardiine
  • 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID
  • 3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine
  • 5-Fluorowillardiine
(all 7)
Definition
An alanine derivative that is L-alanine bearing a 5-fluorouracil-1-yl substituent at position 3. A more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (Ki = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively).
References
(all 13)
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
Phenotype
Phenotype resulting from 3-(5-fluorouracil-1-yl)-L-alanine
Phenotype where environments contain 3-(5-fluorouracil-1-yl)-L-alanine
Phenotype modified by environments containing 3-(5-fluorouracil-1-yl)-L-alanine
Phenotype affecting 3-(5-fluorouracil-1-yl)-L-alanine
Human Disease Model
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