AEE788

Term ID

CHEBI:40629

Synonyms

6-{4-[(4-ethyl-1-piperazinyl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-1H-pyrrolo[2,3-d]pyrimidin-4-amine
6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
[6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-((R)-1-phenylethyl)amine
AEE 788
AEE-788
NVP-AEE-788
NVP-AEE788

Definition

A 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine which adopts an R-configuration. It is a potent inhibitor of human EGFR, VEGFR and HER2 receptor tyrosine kinases and exhibits anticancer and antiangiogenic activity.

References

cas:497839-62-0
chemspider:8472511
drugbank:DB12558
lincs.smallmolecule:LSM-45507
pdb-ccd:AEE
pubmed:15256466
pubmed:15520205
pubmed:15756022
pubmed:15827337
pubmed:16740767
pubmed:16926628
pubmed:17317822
pubmed:17349580
pubmed:17876047
pubmed:18227510
pubmed:18337021
pubmed:18688594
pubmed:18813786
pubmed:19473483
pubmed:19594733
pubmed:19945288
pubmed:20090347
pubmed:20148349
pubmed:20380868
pubmed:20386540
pubmed:20647329
pubmed:20878094
pubmed:20885895
pubmed:20954195
pubmed:21984222
pubmed:22392572
pubmed:22922496
pubmed:23014528
pubmed:24468788
pubmed:26107817
pubmed:28246189
pubmed:30705084
pubmed:31388935
wikipedia.en:AEE788

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from AEE788

Phenotype where environments contain AEE788

Phenotype modified by environments containing AEE788

Phenotype affecting AEE788

Human Disease Model