cyclosporin A

Term ID

CHEBI:4031

Synonyms

(R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)
1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]
30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
Antibiotic S 7481F1
Ciclosporin
ciclosporina
ciclosporine
ciclosporinum
Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl)
cyclosporin A
Cyclosporine
Gengraf
Neoral
Sandimmune

Definition

A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.

References

cas:59865-13-3
chemspider:4447449
drugbank:DB00091
drugcentral:760
hmdb:HMDB0250682
kegg.compound:C05086
kegg.drug:D00184
knapsack:C00001517
lincs.smallmolecule:LSM-1703
lipidmaps:LMPK14000003
metacyc.compound:CPD-20532
patent:US4117118
pubmed:11058832
pubmed:11069928
pubmed:11079273
pubmed:11080188
pubmed:11238591
pubmed:11256490
pubmed:11278005
pubmed:11315347
pubmed:11370709
pubmed:11406057
pubmed:11426833
pubmed:11442023
pubmed:11481617
pubmed:11493684
pubmed:11529914
pubmed:11557554
pubmed:11564166
pubmed:11676831
pubmed:11870366
pubmed:12021257
pubmed:12050171
pubmed:12603598
pubmed:12761440
pubmed:12929192
pubmed:12950728
pubmed:14521916
pubmed:14621732
pubmed:14638917
pubmed:14672695
pubmed:14682659
pubmed:14743390
pubmed:15030555
pubmed:15175101
pubmed:15210365
pubmed:15306697
pubmed:15383526
pubmed:15541012
pubmed:15613074
pubmed:15626898
pubmed:15657176
pubmed:1566062
pubmed:15711594
pubmed:15811524
pubmed:15962181
pubmed:16372476
pubmed:16404634
pubmed:16724420
pubmed:16801218
pubmed:16898534
pubmed:17032751
pubmed:17083576
pubmed:17117422
pubmed:17192032
pubmed:17220244
pubmed:17229932
pubmed:17265451
pubmed:17446460
pubmed:17603747
pubmed:18076075
pubmed:18171316
pubmed:18191430
pubmed:18217899
pubmed:18259730
pubmed:18299432
pubmed:18359899
pubmed:18583716
pubmed:18597363
pubmed:18790203
pubmed:18818682
pubmed:18931077
pubmed:18975184
pubmed:19282398
pubmed:19589783
pubmed:21752960
pubmed:23620378
pubmed:24134630
pubmed:31144214
pubmed:34561200
pubmed:34561814
reaxys:3647785
vsdb:1765
wikipedia.en:Ciclosporin

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from cyclosporin A

Phenotype where environments contain cyclosporin A

Phenotype modified by environments containing cyclosporin A

Phenotype affecting cyclosporin A

Human Disease Model