cosyntropin

Term ID

CHEBI:3901

Synonyms

• adrenocorticotropic hormone 1-24
• alpha(1-24)-corticotrophin
• ATCH (1-24)
• beta(1-24)-corticotrophin
• corticotropin-(1-24)
• corticotropin-(1-24) tetracosapeptide
• Cosyntropin
• L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyline
• SerTyrSerMetGluHisPheArgTrpGlyLysProValGlyLysLysArgArgProValLysValTyrPro
• SYSMEHFRWGKPVGKKRRPVKVYP
• tetracosactide

Definition

A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone (corticotropin). A segment similar in all species, it contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. It is used diagnostically to investigate adrenocortical insufficiency.

References

• cas:16960-16-0
• drugbank:DB01284
• drugcentral:4516
• kegg.drug:D00284
• pmc:PMC10554854
• pmc:PMC8089304
• pmc:PMC8090221
• pmc:PMC8265910
• pmc:PMC9625163
• pubmed:31789828
• pubmed:33978314
• pubmed:35035309
• pubmed:35044272
• pubmed:35487459
• pubmed:36060940
• pubmed:37625985
• pubmed:37651920
• pubmed:37816309
• pubmed:38222249

Ontology

ChEBI  ( EBI )

Resources

CTD