fluvastatin

Term ID

CHEBI:38561

Synonyms

• (+-)-fluvastatin
• (6E)-erythro7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
• Cranoc
• erythro-(E)-3,5-dihydroxy-7-[3'-(4''-fluorophenyl)-1'-(1''-methylethyl)indol-2'-yl]hept-6-enoic acid
• fluvastatin
• fluvastatina
• fluvastatine
• fluvastatinum
• rac-(3R,5S)-fluvastatin
• rac-(3R,5S,6E)-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic acid
• rac-(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid

Definition

A racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin. An HMG-CoA reductase inhibitor, it is used (often as the corresponding sodium salt) to reduce triglycerides and LDL-cholesterol, and increase HDL-chloesterol, in the treatment of hyperlipidaemia.

References

• beilstein:9168031
• cas:93957-54-1
• drugbank:DB01095
• kegg.compound:C07014
• kegg.drug:D07983
• patent:US4739073
• patent:WO8402131
• pubmed:11273020
• pubmed:12147804
• pubmed:18410471
• pubmed:18413661
• pubmed:18452779
• pubmed:18936176
• pubmed:23212095
• pubmed:23846727
• wikipedia.en:Fluvastatin

Ontology

ChEBI  ( EBI )

Resources

CTD