EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor

Term ID

CHEBI:35664

Synonyms

HMG-CoA reductase inhibitor
HMG-CoA reductase inhibitors
hydroxymethylglutaryl-CoA reductase inhibitor
hydroxymethylglutaryl-CoA reductase inhibitors

Definition

Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD⁺ or NADP⁺ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme.

References

pubmed:1464741
pubmed:15531285
pubmed:20467214
wikipedia.en:HMG-CoA_reductase

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor

Phenotype where environments contain EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor

Phenotype modified by environments containing EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor

Phenotype affecting EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor

Human Disease Model