paxilline

Term ID

CHEBI:34907

Synonyms

(+)-paxilline
(2R,4bS,6aS,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-[1]benzopyrano[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one
(2R,4bS,6aS,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one
paxiline
paxillin
paxilline

Definition

An indole diterpene alkaloid with formula C₂₇H₃₃NO₄ isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca₂⁺- and voltage-activated K⁺ (BK)-type channels.

References

cas:57186-25-1
foodb.food:FDB002165
hmdb:HMDB0030323
kegg.compound:C13782
knapsack:C00023582
metacyc.compound:CPD-16744
pubmed:15281747
pubmed:17428785
pubmed:19054419
pubmed:20421373
pubmed:21150246
pubmed:22240184
pubmed:23311903
pubmed:23525886
pubmed:23949005
pubmed:24711838
pubmed:24894186
pubmed:25036831
pubmed:25348413
pubmed:26426046
pubmed:26593869
pubmed:28674820
pubmed:29237259
pubmed:30518785
pubmed:31009898
pubmed:31879339
pubmed:32030976
pubmed:32244116
pubmed:33071366
pubmed:33329012
pubmed:34931646
pubmed:35504559
pubmed:3912307
reaxys:5317894
wikipedia.en:Paxilline

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from paxilline

Phenotype where environments contain paxilline

Phenotype modified by environments containing paxilline

Phenotype affecting paxilline

Human Disease Model