NS 1619

Term ID

CHEBI:34879

Synonyms

• 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
• 1-(2'-hydroxy-5'-trifluoromethylphenyl)-5-trifluoromethyl-2(3H)-benzimidazolone
• 1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one
• 5-trifluoromethyl-2,3-dihydro-1-(5-trifluoromethyl-2-hydroxyphenyl)-1H-2-oxo-benzimidazole
• NS-1619
• NS1619

Definition

A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).

References

• cas:153587-01-0
• kegg.compound:C13833
• lincs.smallmolecule:LSM-3206
• pubmed:15543339
• pubmed:18706395
• pubmed:21415309
• pubmed:21441626
• pubmed:24398773
• pubmed:24497961
• pubmed:24813114
• pubmed:7534190
• pubmed:7589189
• pubmed:9151934
• reaxys:8165035

Ontology

ChEBI  ( EBI )

Resources

CTD