dizocilpine

Term ID

CHEBI:34725

Synonyms

(+)-dizocilpine
(+)-MK-801
(5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene
dizocilpina
dizocilpine
dizocilpinum
MK 801
MK-801
MK801

Definition

An organic heterotetracyclic compound that is 1-methyl-8-azabicyclo[3.2.1]octane ortho-fused to two benzene rings at positions 2-3 and 6-7 (the 5S,10R-stereoisomer). It is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and affects cognitive function, learning, and memory.

References

cas:77086-21-6
chemspider:156718
kegg.compound:C13737
lincs.smallmolecule:LSM-5688
pdb-ccd:BMK
pubmed:28232581
pubmed:29489358
pubmed:29670280
pubmed:30772438
pubmed:31177060
pubmed:32105720
pubmed:32219769
pubmed:32289529
pubmed:32324160
pubmed:32641944
pubmed:32760846
pubmed:32808583
pubmed:32892308
pubmed:32956214
pubmed:32973585
pubmed:33187817
pubmed:33249825
pubmed:33324181
pubmed:33404734
pubmed:33442771
pubmed:33639267
pubmed:33656787
pubmed:33723767
pubmed:33809889
pubmed:33882624
pubmed:33891976
pubmed:33945878
pubmed:33974921
pubmed:34054433
pubmed:34098454
pubmed:34119597
pubmed:34177484
wikipedia.en:Dizocilpine

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from dizocilpine

Phenotype where environments contain dizocilpine

Phenotype modified by environments containing dizocilpine

Phenotype affecting dizocilpine

Human Disease Model