soblidotin

Term ID

CHEBI:32135

Synonyms

• N,N-dimethyl-L-valyl-N-{(3R,4S,5S)-3-methoxy-1-[(2S)-2-{(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl}pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl}-N-methyl-L-valinamide
• soblidotin
• soblidotina
• soblidotine
• soblidotinum
• TZT 1027
• TZT-1027

Definition

A tetrapeptide derivative of dolastatin 10. It is an inhibitor of tubulin polymerization which exhibits potent antitumor activity.

References

• cas:149606-27-9
• drugbank:DB12677
• kegg.drug:D01919
• patent:US7008928
• pubmed:10629886
• pubmed:10920282
• pubmed:10965026
• pubmed:11227216
• pubmed:11678375
• pubmed:12967483
• pubmed:15330161
• pubmed:15897580
• pubmed:16141595
• pubmed:16550209
• pubmed:16619516
• pubmed:16827132
• pubmed:16999818
• pubmed:17092603
• pubmed:17109446
• pubmed:17136542
• pubmed:17284247
• pubmed:17436580
• pubmed:17473826
• pubmed:17667596
• pubmed:18214483
• pubmed:18225550
• pubmed:19068085
• pubmed:20145173
• pubmed:27136567
• pubmed:30901820
• pubmed:33251248
• pubmed:9140117

Ontology

ChEBI  ( EBI )

Resources

CTD