nemonapride

Term ID

CHEBI:31899

Synonyms

(+-)-cis-N-(1-benzyl-2-methyl-3-pyrrolidinyl)-5-chloro-4-(methylamino)-o-anisamide
(+-)-cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide
(+-)-nemonapride
Emilace
emonapride
nemonaprida
nemonapride
nemonapridum
rac-N-[(2S,3S)-1-benzyl-2-methylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-(methylamino)benzamide
rac-nemonapride
racemic nemonapride
YM 09151-2
YM-09151

Definition

A racemate composed of (2S,3S)- and (2R,3R)-enantiomers of nemonapride. Highly potent dopamine D₂-like receptor antagonist; selective over D₁-like receptors (Ki values are 0.1 and 740 nM for D₂-like and D₁-like receptors respectively). Also potent 5-HT_1A receptor agonist (IC₅₀ = 34 nM) and has affinity for sigma receptors.

References

cas:75272-39-8
drugcentral:1895
kegg.compound:C12915
kegg.drug:D01468
patent:EP1273301
patent:US5811547
pubmed:10049714
pubmed:10363800
pubmed:10435376
pubmed:10587100
pubmed:10823405
pubmed:10862524
pubmed:10898926
pubmed:10917400
pubmed:11817505
pubmed:11929700
pubmed:16020947
pubmed:8328325
pubmed:9016292
pubmed:9031995
pubmed:9095318
pubmed:9228185
pubmed:9310388
pubmed:9325557
pubmed:9369342
pubmed:9766869
pubmed:9774248
pubmed:9934942
reaxys:5766104
wikipedia.en:Nemonapride

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from nemonapride

Phenotype where environments contain nemonapride

Phenotype modified by environments containing nemonapride

Phenotype affecting nemonapride

Human Disease Model